10mg lyophilized vial
Longevity · Research Peptide
Mitochondria-targeted tetrapeptide for cellular energy repair.
01 · Overview
SS-31 (elamipretide) is a rationally designed tetrapeptide built to do one thing: get into mitochondria and fix the membrane. It selectively binds cardiolipin — a fat unique to the inner mitochondrial membrane that degrades with age and disease — and stabilizes the machinery that produces ATP.
That makes it different from most 'energy' compounds. Caffeine borrows energy; NAD+ supplies raw material; SS-31 repairs the generator itself. It's been through human clinical trials for mitochondrial myopathy, heart failure, and age-related kidney decline, and it remains one of the more mechanistically credible longevity peptides in active research.
02 · Fit
People chasing the energy floor — those who feel their cellular battery draining faster than it should, especially alongside NAD+ protocols.
03 · Mechanism
SS-31 (elamipretide) is a mitochondria-targeted peptide that binds cardiolipin in the inner mitochondrial membrane, stabilizing the electron transport chain, improving ATP output, and reducing reactive oxygen species at the source.
04 · Use cases
05 · Protocols
Reference protocols paraphrased from published research and common clinical practice. Individual response varies. Work with a qualified provider before running anything below.
General mitochondrial support
Protocol
1–2mg subcutaneous once daily
Duration
4–6 weeks on, 4 weeks off
Notes
Energy and endurance changes are usually reported in weeks 2–4.
Intensive block
Protocol
2mg subcutaneous twice daily
Duration
2–4 weeks
Notes
Reserved for shorter pushes; monitor for injection-site irritation with twice-daily dosing.
Baseline reconstitution
Reconstitute 10mg with 2ml BAC water for 5mg/ml.
06 · Combinations
The natural partner is NAD+ — SS-31 repairs the mitochondrial membrane while NAD+ feeds the reactions inside it. MOTS-c is the other common addition for a full mitochondrial stack.
07 · Safety
08 · Trivia
09 · FAQ
NAD+ is fuel — a raw material your cells burn. SS-31 is maintenance — it stabilizes the mitochondrial membrane so the engine runs efficiently. They address different failure points and pair well.
It's not a stimulant — no instant lift. Most reported changes in energy and endurance show up in weeks 2–4 of daily use.
No. MOTS-c is encoded by your own mitochondrial DNA and works on metabolic signaling. SS-31 is synthetic and works on membrane structure. Different mechanisms, complementary effects.
Educational disclaimer
Everything on this page is for research and educational purposes only. It is not medical advice, a prescription, or a substitute for a conversation with a qualified clinician who knows your full history. Peptides interact with medications, hormones, and existing conditions in ways that require real oversight.