10mg lyophilized vial
Growth · Research Peptide
GHRH analog stimulating endogenous growth hormone release.
01 · Overview
Sermorelin is a 29-amino-acid analog of GHRH (growth hormone-releasing hormone) — the natural signal your hypothalamus sends the pituitary to release GH. Instead of injecting exogenous HGH (which shuts down your own production), sermorelin nudges the pituitary to release its own GH in a natural pulse.
The practical difference: pulsatile release preserves the negative feedback loop, so IGF-1 stays in a physiological range and the pituitary doesn't atrophy. It was FDA-approved for pediatric GH deficiency in the 1990s (Geref) before being pulled from the market for commercial reasons, and it's now widely used off-label by anti-aging clinics.
02 · Fit
35+ users noticing worse sleep and slower recovery who want a gentler on-ramp than exogenous HGH.
03 · Mechanism
Sermorelin binds the GHRH receptor in the pituitary, prompting pulsatile secretion of endogenous growth hormone while preserving negative feedback.
04 · Use cases
05 · Protocols
Reference protocols paraphrased from published research and common clinical practice. Individual response varies. Work with a qualified provider before running anything below.
Standard anti-aging / recovery
Protocol
200–300mcg subcutaneous before bed
Duration
5 days on, 2 days off, for 3–6 months
Notes
The pre-bed pulse aligns with your natural GH peak during slow-wave sleep.
Body-composition focus
Protocol
300mcg pre-bed AND 200mcg post-workout
Duration
12–16 weeks on, 4–6 weeks off
Notes
Two pulses per day compound the effect but cycle off to preserve receptor sensitivity.
Baseline reconstitution
Reconstitute 10mg with 2ml BAC water for 5mg/ml.
06 · Combinations
Frequently combined with a GHRP (like ipamorelin) for a stronger, cleaner pulse. Also pairs with tesamorelin for visceral fat targeting, and with TB-500 for connective-tissue support during training.
07 · Safety
08 · Trivia
09 · FAQ
HGH is stronger but overrides your natural axis and carries more risk. Sermorelin works with your biology — smaller effect, cleaner profile, safer long-term.
Your biggest natural GH pulse happens in early slow-wave sleep. Sermorelin dosed at bedtime amplifies that pulse.
Yes — high blood sugar blunts GH release. Avoid carbs for 2 hours before and 30 minutes after.
Educational disclaimer
Everything on this page is for research and educational purposes only. It is not medical advice, a prescription, or a substitute for a conversation with a qualified clinician who knows your full history. Peptides interact with medications, hormones, and existing conditions in ways that require real oversight.