01 · Overview
NAD+ (nicotinamide adenine dinucleotide) isn't technically a peptide — it's a coenzyme — but it's a mainstay of the peptide-clinic world. Every mitochondrion in your body needs NAD+ to make ATP. It's also the substrate for sirtuins (the 'longevity genes') and PARPs (which repair DNA damage).
NAD+ levels drop roughly 50% between age 20 and age 60. Restoring them via direct injection or IV is the fastest way to raise intracellular NAD+ — oral precursors like NR and NMN work through slower metabolic pathways. It's the flagship longevity intervention Peter Attia, David Sinclair, and most anti-aging clinicians talk about.
02 · Fit
40+ users, biohackers, and anyone noticing an energy floor drop — the flagship longevity coenzyme.
03 · Mechanism
NAD+ is a critical coenzyme in redox reactions and a substrate for sirtuins and PARPs, both central to DNA repair and mitochondrial biogenesis.
04 · Use cases
05 · Protocols
Reference protocols paraphrased from published research and common clinical practice. Individual response varies. Work with a qualified provider before running anything below.
Daily maintenance
Protocol
100mg subcutaneous once daily (morning)
Duration
Ongoing, with a 1-week break every 8 weeks
Notes
Small daily doses avoid the intense IV drip experience.
Loading / restoration
Protocol
500–1000mg IV weekly for 4 weeks, then transition to subcutaneous maintenance
Duration
4-week IV loading, then daily/weekly subcutaneous
Notes
IV loading is the standard 'age-reset' clinic protocol.
Baseline reconstitution
Reconstitute 1000mg with 10ml BAC water for 100mg/ml.
06 · Combinations
Pairs with glutathione (energy + antioxidant), MOTS-c (mitochondrial signaling), and resveratrol/pterostilbene as sirtuin activators. Many longevity protocols run all four in the same week.
07 · Safety
08 · Trivia
09 · FAQ
IV: fastest and most dramatic, uncomfortable. Subcutaneous: convenient, well tolerated, still raises intracellular NAD+. Oral NR/NMN: slower, milder, but great for daily maintenance.
Fast delivery activates receptors in the chest wall — pressure and flushing. Slow the drip and it's very manageable. Subcutaneous avoids it entirely.
IV: within the drip. Subcutaneous: most users notice a lift in energy and mental clarity in 5–10 days of consistent dosing.
Educational disclaimer
Everything on this page is for research and educational purposes only. It is not medical advice, a prescription, or a substitute for a conversation with a qualified clinician who knows your full history. Peptides interact with medications, hormones, and existing conditions in ways that require real oversight.